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Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury

16 Feb 2024

Abstract excerpt

Tubular injury is the hallmark of acute kidney injury (AKI) with a tremendous impact on patients and health-care systems. During injury, any differentiated proximal tubular cell (PT) may transition into a specific injured phenotype, so-called "scattered tubular cell" (STC)-phenotype. To understand the fate of this specific phenotype, we generated transgenic mice allowing inducible, reversible, and irreversible...

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PMID: 38444605
DOI: 10.1016/j.isci.2024.109255

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