Replicated evidence for aminoacylase 3 and nephrin gene variations to predict antihypertensive drug responses.

doi:10.2217/pgs-2016-0204

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Article

Replicated evidence for aminoacylase 3 and nephrin gene variations to predict antihypertensive drug responses.

Pharmacogenomics - 1 Apr 2017

Rimpelä Jenni M, Kontula Kimmo K, Fyhrquist Frej, Donner Kati M, Tuiskula Annukka M, Sarin Antti-Pekka, Mohney Robert P, Stirdivant Steven M, Hiltunen Timo P

Abstract excerpt

AIM: To replicate the genome-wide associations of the antihypertensive effects of bisoprolol and losartan in GENRES, using the Finnish patients of LIFE study. PATIENTS & METHODS: We analyzed association of four SNPs with atenolol and three SNPs with losartan response in 927 Finnish LIFE patients (467 for atenolol and 460 for losartan). RESULTS: rs2514036, a variation at a transcription start site of ACY3, was...

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PMID: 28353407
DOI: 10.2217/pgs-2016-0204

Genes

ACY3
NPHS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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