Genetic factors associated with elevation of uric acid after treatment with thiazide-like diuretic in patients with essential hypertension.

doi:10.1038/s41440-019-0356-x

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Genetic factors associated with elevation of uric acid after treatment with thiazide-like diuretic in patients with essential hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Mar 2020

Ohta Yuko, Kamide Kei, Hanada Hironori, Morimoto Shigeto, Nakahashi Takeshi, Takiuchi Shin, Ishimitsu Toshihiko, Tsuchihashi Takuya, Soma Masayoshi, Tomohiro Katsuya T, Sugimoto Ken, Rakugi Hiromi, Oukura Takafumi, Higaki Jitsuo, Matsuura Hideo, Shinagawa Tatsuo, Miwa Yosikazu, Sasaguri Toshiyuki, Igase Michiya, Miki Tetsuro, Takeda Kazuo, Higashiura Katsuhiro, Shimamoto Kazuaki, Katabuchi Ritsuko, Ueno Michio, Hosomi Naonaga, Kato Johji, Komai Norio, Kojima Shunichi, Sase Kazuhiro, Iwashima Yoshio, Yoshihara Fumiki, Horio Takeshi, Nakamura Satoko, Nakahama Hajime, Miyata Toshiyuki, Kawano Yuhei

Abstract excerpt

We investigated changes in blood pressure (BP) and metabolic adverse effects, especially elevation of uric acid (UA), after treatment with a thiazide-like diuretic (TD) in patients with essential hypertension. Furthermore, the role of genetic factors in the elevation of UA by TD was assessed by a 500 K SNP DNA microarray. The subjects included 126 hypertensive patients (57 women and 69 men, mean age 59 ± 12...

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PMID: 31748705
DOI: 10.1038/s41440-019-0356-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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