Article
O-GlcNAc site-mapping of liver X receptor-α and O-GlcNAc transferase.
Biochemical and biophysical research communications - 5 May 2018
Fan Qiong, Moen Anders, Anonsen Jan Haug, Bindesbøll Christian, Sæther Thomas, Carlson Cathrine Rein, Grønning-Wang Line M
Abstract excerpt
The Liver X Receptor α (LXRα) belongs to the nuclear receptor superfamily and plays an essential role in regulating cholesterol, lipid and glucose metabolism and inflammatory responses. We have previously shown that LXRα is post-translationally modified by O-linked β-N-acetyl-glucosamine (O-GlcNAc) with increased transcriptional activity. Moreover, we showed that LXRα associates with O-GlcNAc transferase (OGT)...
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