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Article

Cyclic AMP and glycogen synthase kinase 3 form a regulatory loop in spermatozoa.

Journal of cellular physiology - 1 Sept 2018

Dey Souvik, Goswami Suranjana, Eisa Alaa, Bhattacharjee Rahul, Brothag Cameron, Kline Douglas, Vijayaraghavan Srinivasan

Abstract excerpt

The multifaceted glycogen synthase kinase (GSK3) has an essential role in sperm and male fertility. Since cyclic AMP (cAMP) plays an important role in sperm function, we investigated whether GSK3 and cAMP pathways may be interrelated. We used GSK3 and soluble adenylyl cyclase (sAC) knockout mice and pharmacological modulators to examine this relationship. Intracellular cAMP levels were found to be significantly...

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Source

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Identifiers

PMID: 29574946
DOI: 10.1002/jcp.26557
PMCID: PMC6852663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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