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Article

Isoform-specific requirement for GSK3α in sperm for male fertility.

Biology of reproduction - 1 Aug 2018

Bhattacharjee Rahul, Goswami Suranjana, Dey Souvik, Gangoda Mahinda, Brothag Cameron, Eisa Alaa, Woodgett James, Phiel Christopher, Kline Douglas, Vijayaraghavan Srinivasan

Abstract excerpt

Glycogen synthase kinase 3 (GSK3) is a highly conserved protein kinase regulating key cellular functions. Its two isoforms, GSK3α and GSK3β, are encoded by distinct genes. In most tissues the two isoforms are functionally interchangeable, except in the developing embryo where GSK3β is essential. One functional allele of either of the two isoforms is sufficient to maintain normal tissue functions. Both GSK3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29385396
DOI: 10.1093/biolre/ioy020
PMCID: PMC6692850

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