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Article

Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility.

Biology of reproduction - 1 Mar 2015

Bhattacharjee Rahul, Goswami Suranjana, Dudiki Tejasvi, Popkie Anthony P, Phiel Christopher J, Kline Douglas, Vijayaraghavan Srinivasan

Abstract excerpt

The signaling enzyme glycogen synthase kinase 3 (GSK3) exists as two isoforms-GSK3A and GSK3B. Protein phosphorylation by GSK3 has important signaling roles in several cells. In our past work, we found that both isoforms of GSK3 are present in mouse sperm and that catalytic GSK3 activity correlates with motility of sperm from several species. Here, we examined the role of Gsk3a in male fertility using a targeted...

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Identifiers

PMID: 25568307
DOI: 10.1095/biolreprod.114.124495
PMCID: PMC4358024

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