Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility

15 Jul 2004

Abstract excerpt

Since cAMP blocks meiotic maturation of mammalian and amphibian oocytes in vitro and cyclic nucleotide phosphodiesterase 3A (PDE3A) is primarily responsible for oocyte cAMP hydrolysis, we generated PDE3A-deficient mice by homologous recombination. The Pde3a(-/-) females were viable and ovulated a normal number of oocytes but were completely infertile, because ovulated oocytes were arrested at the germinal vesicle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phosphodiesterase function and regulation
Share to Reproductive Biology and Fertility
Share to Sexual function and dysfunction studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15254586
DOI: 10.1172/jci21804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertilityPMID 15254586Read ↗

Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice.Semantic proximity Read ↗

Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.Semantic proximity Read ↗

Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation.Semantic proximity Read ↗

Towards a new understanding on the regulation of mammalian oocyte meiosis resumptionSemantic proximity Read ↗

PKA, Germ Cells, and FertilitySemantic proximity Read ↗

Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cellsSemantic proximity Read ↗

Effect of temporary nuclear arrest by Phosphodiesterase 3‐Inhibitor on morphological and functional aspects of in vitro matured mouse oocytesSemantic proximity Read ↗

The art of oocyte meiotic arrest regulationSemantic proximity Read ↗

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyteSemantic proximity Read ↗

Selective Regulation of Oocyte Meiotic Events Enhances Progress in Fertility Preservation MethodsSemantic proximity Read ↗

Phosphodiesterase Regulation Is Critical for the Differentiation and Pattern of Gene Expression in Granulosa Cells of the Ovarian FollicleSemantic proximity Read ↗

Human Oocytes Reversibly Arrested in Prophase I by Phosphodiesterase Type 3 Inhibitor In Vitro1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.