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AKAP3-mediated type I PKA signaling is required for mouse sperm hyperactivation and fertility

22 Dec 2023

Abstract excerpt

The protein kinase A (PKA) signaling pathway, which mediates protein phosphorylation, is important for sperm motility and male fertility. This process relies on A-kinase anchoring proteins that organize PKA and its signalosomes within specific subcellular compartments. Previously, it was found that the absence of A-kinase anchoring protein 3 (AKAP3) leads to multiple morphological abnormalities in mouse sperm....

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PMID: 38145487
DOI: 10.1093/biolre/ioad180

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