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Article

Signaling Enzymes Required for Sperm Maturation and Fertilization in Mammals

18 Dec 2019

Abstract excerpt

In mammals, motility and fertilizing ability of spermatozoa develop during their passage through the epididymis. After ejaculation, sperm undergo capacitation and hyperactivation in the female reproductive tract - a motility transition that is required for sperm penetration of the egg. Both epididymal initiation of sperm motility and hyperactivation are essential for male fertility. Motility initiation in the...

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PMID: 31921853
DOI: 10.3389/fcell.2019.00341

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