Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isoform-specific GSK3A activity is negatively correlated with human sperm motility

19 Feb 2019

Abstract excerpt

In mouse and bovine sperm, GSK3 activity is inversely proportional to motility. Targeted disruption of the GSK3A gene in testis results in normal spermatogenesis, but mature sperm present a reduced motility, rendering male mice infertile. On the other hand, GSK3B testis-specific KO is fertile. Yet in human sperm, an isoform-specific correlation between GSK3A and sperm motility was never established. In order to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Genetics and Reproduction
Share to Sperm and Testicular Function
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30824926
DOI: 10.1093/molehr/gaz009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isoform-specific GSK3A activity is negatively correlated with human sperm motilityPMID 30824926Read ↗

Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility.Semantic proximity Read ↗

Isoform-specific requirement for GSK3α in sperm for male fertility.Semantic proximity Read ↗

Characteristics of testis-specific phosphoglycerate kinase 2 and its association with human sperm qualitySemantic proximity Read ↗

Testis‐specific serine kinase 3 is required for sperm morphogenesis and male fertilitySemantic proximity Read ↗

Human sperm phosphoproteome reveals differential phosphoprotein signatures that regulate human sperm motilitySemantic proximity Read ↗

Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertilitySemantic proximity Read ↗

Signaling Enzymes Required for Sperm Maturation and Fertilization in MammalsSemantic proximity Read ↗

Mutations in the prostate specific antigen (PSA/KLK3) correlate with male infertility.Semantic proximity Read ↗

Phosphatidylinositol 3-kinase inhibition enhances human sperm motilitySemantic proximity Read ↗

Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzymeSemantic proximity Read ↗

Localization of AKAP4 and tubulin proteins in sperm with reduced motilitySemantic proximity Read ↗

Decoding human sperm signalling: Phosphoproteomic discovery of kinases governing fertilization competencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.