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Article

Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation.

The EMBO journal - 13 Dec 2006

Han Seung Jin, Vaccari Sergio, Nedachi Taku, Andersen Carsten B, Kovacina Kristina S, Roth Richard A, Conti Marco

Abstract excerpt

cGMP-inhibited cAMP phosphodiesterase 3A (PDE3A) is expressed in mouse oocytes, and its function is indispensable for meiotic maturation as demonstrated by genetic ablation. Moreover, PDE3 activity is required for insulin/insulin-like growth factor-1 stimulation of Xenopus oocyte meiotic resumption. Here, we investigated the cAMP-dependent protein kinase B (PKB)/Akt regulation of PDE3A and its impact on oocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17124499
DOI: 10.1038/sj.emboj.7601431
PMCID: PMC1698880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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