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Article

Genetic Risk Score Is Associated With Prevalence of Advanced Neoplasms in a Colorectal Cancer Screening Population.

Gastroenterology - 1 Jul 2018

Weigl Korbinian, Thomsen Hauke, Balavarca Yesilda, Hellwege Jacklyn N, Shrubsole Martha J, Brenner Hermann

Abstract excerpt

BACKGROUND & AIMS: The presence of specific single nucleotide polymorphisms (SNPs) can be used to calculate an individual's risk for colorectal cancer (CRC), called a genetic risk score (GRS). We investigated whether GRS can identify individuals with clinically relevant neoplasms in a screening colonoscopy population. METHODS: We derived a GRS based on 48 SNPs associated with CRC, identified in a comprehensive...

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Identifiers

PMID: 29574091
DOI: 10.1053/j.gastro.2018.03.030
PMCID: PMC6035076

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