Article
Association of genetic variants for colorectal cancer differs by subtypes of polyps in the colorectum.
Carcinogenesis - 1 Dec 2012
Zhang Ben, Shrubsole Martha J, Li Guoliang, Cai Qiuyin, Edwards Todd, Smalley Walter E, Ness Reid M, Zheng Wei
Abstract excerpt
Most colorectal cancers originate from polyps, however, only a small proportion of polyps progress to carcinomas. Genome-wide association studies have identified multiple single-nucleotide polymorphisms (SNPs) in relation to colorectal cancer. Using these genetic risk variants, we evaluated whether colorectal cancer genetic factors may determine certain polyp phenotypes with different malignant potential. We...
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