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Article

Colorectal cancer susceptibility variants and risk of conventional adenomas and serrated polyps: results from three cohort studies.

International journal of epidemiology - 1 Feb 2020

Hang Dong, Joshi Amit D, He Xiaosheng, Chan Andrew T, Jovani Manol, Gala Manish K, Ogino Shuji, Kraft Peter, Turman Constance, Peters Ulrike, Bien Stephanie A, Lin Yi, Hu Zhibin, Shen Hongbing, Wu Kana, Giovannucci Edward L, Song Mingyang

Abstract excerpt

BACKGROUND: Increasing evidence suggests that conventional adenomas (CAs) and serrated polyps (SPs) represent two distinct groups of precursor lesions for colorectal cancer (CRC). The influence of common genetic variants on risk of CAs and SPs remain largely unknown. METHODS: Among 27 426 participants within three prospective cohort studies, we created a weighted genetic risk score (GRS) based on 40 CRC-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31038671
DOI: 10.1093/ije/dyz096
PMCID: PMC7426026

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