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Article

Boosting phagocytosis and anti-inflammatory phenotype in microglia mediates neuroprotection by PPARγ agonist MDG548 in Parkinson's disease models.

British journal of pharmacology - 1 Aug 2018

Lecca Daniela, Janda Elzbieta, Mulas Giovanna, Diana Andrea, Martino Concetta, Angius Fabrizio, Spolitu Stefano, Casu Maria Antonietta, Simbula Gabriella, Boi Laura, Batetta Barbara, Spiga Saturnino, Carta Anna R

Abstract excerpt

BACKGROUND AND PURPOSE: Microglial phenotype and phagocytic activity are deregulated in Parkinson's disease (PD). PPARγ agonists are neuroprotective in experimental PD, but their role in regulating microglial phenotype and phagocytosis has been poorly investigated. We addressed it by using the PPARγ agonist MDG548. EXPERIMENTAL APPROACH: Murine microglial cell line MMGT12 was stimulated with LPS and/or MDG548,...

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Identifiers

PMID: 29570770
DOI: 10.1111/bph.14214
PMCID: PMC6057897

Genes

MRC1
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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