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Article

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ.

Haematologica - 1 Jun 2018

Hrdinová Johana, Verbij Fabian C, Kaijen Paul H P, Hartholt Robin B, van Alphen Floris, Lardy Neubury, Ten Brinke Anja, Vanhoorelbeke Karen, Hindocha Pooja J, De Groot Anne S, Meijer Alexander B, Voorberg Jan, Peyron Ivan

Abstract excerpt

Formation of microthrombi is a hallmark of acquired thrombotic thrombocytopenic purpura. These microthrombi originate from insufficient processing of ultra large von Willebrand factor multimers by ADAMTS13 due to the development of anti-ADAMTS13 autoantibodies. Several studies have identified the major histocompatibility complex class II alleles HLA-DRB1*11, HLA-DQB1*03 and HLA-DQB1*02:02 as risk factors for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29567779
DOI: 10.3324/haematol.2017.179119
PMCID: PMC6058777

Genes

ADAMTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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