Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging Concepts in Immune Thrombotic Thrombocytopenic Purpura.

Frontiers in immunology - 1 Jan 2021

Laghmouchi Aicha, Graça Nuno A G, Voorberg Jan

Abstract excerpt

Immune thrombotic thrombocytopenic purpura (iTTP) is an autoimmune disorder of which the etiology is not fully understood. Autoantibodies targeting ADAMTS13 in iTTP patients have extensively been studied, the immunological mechanisms leading to the breach of tolerance remain to be uncovered. This review addresses the current knowledge on genetic factors associated with the development of iTTP and the interplay...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAMTS13 Protein
Share to Antigen-Presenting Cells
Share to Immunity, Mucosal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Mimicry

Share to Purpura, Thrombotic Thrombocytopenic

Share to Self Tolerance

Share to Toll-Like Receptor 9

Share to Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 34858410
DOI: 10.3389/fimmu.2021.757192
PMCID: PMC8631936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging Concepts in Immune Thrombotic Thrombocytopenic Purpura.PMID 34858410Read ↗

Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers.Semantic proximity Read ↗

HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR.Semantic proximity Read ↗

[Immune-mediated thrombotic thrombocytopenic purpura and susceptible HLA alleles].Semantic proximity Read ↗

Identification of HLA alleles involved in immune thrombotic thrombocytopenic purpura patients from Turkey.Semantic proximity Read ↗

Pathogenesis in immune thrombocytopenia: new insights.Semantic proximity Read ↗

Genetics of thrombotic thrombocytopenic purpura: systematic review in immune and congenital thrombotic thrombocytopenic purpura.Semantic proximity Read ↗

Acquired thrombotic thrombocytopenic purpura without detectable anti-ADAMTS13 antibodies: a possible underlying autoimmune mechanism.Semantic proximity Read ↗

The ADAMTS131239-1253 peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope.Semantic proximity Read ↗

The pathogenesis of immune thrombocytopaenic purpura.Semantic proximity Read ↗

A Systematic Review and Meta-Analysis of HLA-Class-II Associations in Patients with IgG4 AutoimmunitySemantic proximity Read ↗

Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link.Semantic proximity Read ↗

HLAs in Autoimmune Diseases: Dependable Diagnostic Biomarkers?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.