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Article

[Immune-mediated thrombotic thrombocytopenic purpura and susceptible HLA alleles].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2022

Sakai Kazuya

Abstract excerpt

Thrombotic thrombocytopenic purpura (TTP) is an extremely rare and fatal thrombotic disorder characterized by impaired enzyme activity of von Willebrand factor cleaving protease, also known as ADAMTS13. Immune-mediated TTP (iTTP) is an acquired form of TTP caused by the production of auto-antibodies against ADAMTS13. The pathophysiology of autoimmune disorders is multifactorial, with several human leukocyte...

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Identifiers

PMID: 35491217
DOI: 10.11406/rinketsu.63.277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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