HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR.

doi:10.1182/blood.2020005395

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Article

HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR.

Blood - 25 Jun 2020

Sakai Kazuya, Kuwana Masataka, Tanaka Hidenori, Hosomichi Kazuyoshi, Hasegawa Atsushi, Uyama Hiroki, Nishio Kenji, Omae Takashi, Hishizawa Masakatsu, Matsui Masashi, Iwato Koji, Okamoto Akinao, Okuhiro Kazuki, Yamashita Yukiko, Itoh Masataka, Kumekawa Hanae, Takezako Naoki, Kawano Noriaki, Matsukawa Toshihiro, Sano Haruna, Ohshiro Kazuiku, Hayashi Kunio, Ueda Yasunori, Mushino Toshiki, Ogawa Yoshiyuki, Yamada Yuji, Murata Mitsuru, Matsumoto Masanori

Abstract excerpt

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare autoimmune disorder caused by neutralizing anti-ADAMTS13 autoantibodies. In white individuals, HLA allele DRB1*11 is a predisposing factor for iTTP, whereas DRB1*04 is a protective factor. However, the role of HLA in Asians is unclear. In this study, we analyzed 10 HLA loci using next-generation sequencing in 52 Japanese patients with iTTP, and...

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PMID: 32253422
DOI: 10.1182/blood.2020005395

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