Article
Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers.
Haematologica - 1 Jul 2018
Hrdinová Johana, D'Angelo Silvia, Graça Nuno A G, Ercig Bogac, Vanhoorelbeke Karen, Veyradier Agnès, Voorberg Jan, Coppo Paul
Abstract excerpt
Although outstanding progress has been made in understanding the pathophysiology of thrombotic thrombocytopenic purpura (TTP), knowledge of the immunopathogenesis of the disease is only at an early stage. Anti-ADAMTS13 auto-antibodies were shown to block proteolysis of von Willebrand factor and/or induce ADAMTS13 clearance from the circulation. However, it still remains to identify which immune cells are involved...
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