Article
Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome.
Molecular immunology - 1 Mar 2016
Iatropoulos Paraskevas, Noris Marina, Mele Caterina, Piras Rossella, Valoti Elisabetta, Bresin Elena, Curreri Manuela, Mondo Elena, Zito Anna, Gamba Sara, Bettoni Serena, Murer Luisa, Fremeaux-Bacchi Veronique, Vivarelli Marina, Emma Francesco, Daina Erica, Remuzzi Giuseppe
Abstract excerpt
BACKGROUND: Membranoproliferative glomerulonephritis (MPGN) is an uncommon cause of chronic nephropathy recently reclassified into immunoglobulin-associated MPGN (Ig-MPGN) and C3 glomerulopathy (C3G). In this study we aimed: (1) to evaluate the complement genetic and biochemical profile in patients with Ig-MPGN/C3G; (2) to investigate whether genetic variants and different patterns of complement activation (i.e.,...
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