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Article

Large-Scale Whole-Genome Sequencing Reveals the Genetic Architecture of Primary Membranoproliferative GN and C3 Glomerulopathy

9 Jan 2020

Abstract excerpt

Significance Statement A minority of cases of primary membranoproliferative GN are familial, caused by mutations in complement genes, and nonfamilial cases have also been reported to harbor such mutations. To characterize the genetic factors contributing to this disease, the authors analyzed whole-genome data from 165 cases of primary membranoproliferative GN and 10,250 control individuals, including 146 cases...

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PMID: 31919107
DOI: 10.1681/asn.2019040433

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