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Article

FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma.

Oncology reports - 1 May 2018

Hu Xiaoling, Zhai Yuanfang, Shi Ruyi, Qian Yu, Cui Heyang, Yang Jie, Bi Yanghui, Yan Ting, Yang Jian, Ma Yanchun, Zhang Ling, Liu Yiqian, Li Guodong, Zhang Mingsheng, Cui Yongping, Kong Pengzhou, Cheng Xiaolong

Abstract excerpt

FAT atypical cadherin 1 (FAT1) belongs to the cadherin superfamily and has been reported to regulate cell‑cell adhesion and other cell behaviors, suggesting its pivotal roles in human cancers. We previously identified FAT1 as one of the significant mutant genes in esophageal squamous cell carcinoma (ESCC). In the present study, the knockdown of FAT1 expression in YSE2 and Colo680N cell lines was carried out by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29565465
DOI: 10.3892/or.2018.6328
PMCID: PMC5928768

Genes

FAT1
AFM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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