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Article

L1CAM drives oncogenicity in esophageal squamous cell carcinoma by stimulation of ezrin transcription.

Journal of molecular medicine (Berlin, Germany) - 1 Dec 2017

Guo Jin-Cheng, Xie Yang-Min, Ran Li-Qiang, Cao Hui-Hui, Sun Chun, Wu Jian-Yi, Wu Zhi-Yong, Liao Lian-Di, Zhao Wei-Jiang, Fang Wang-Kai, Li En-Min, Xu Li-Yan, Schachner Melitta, Xie Jian-Jun

Abstract excerpt

L1 cell adhesion molecule (L1CAM) is highly expressed in various types of human cancers, displaying yet unknown molecular mechanisms underlying their oncogenic potential. Here, we found that L1CAM expression was significantly increased in esophageal squamous cell carcinoma (ESCC; n = 157) lesions compared with non-cancerous tissues. High tumorous L1CAM expression significantly correlated with reduced overall...

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Carcinogenesis
Esophageal Neoplasms
Esophageal Squamous Cell Carcinoma
Gene Silencing
Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Invasiveness

Neural Cell Adhesion Molecule L1

Subcellular Fractions

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PMID: 28939985
DOI: 10.1007/s00109-017-1595-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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