T-bet deficiency attenuates cardiac remodelling in rats.

doi:10.1007/s00395-018-0678-x

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Article

T-bet deficiency attenuates cardiac remodelling in rats.

Basic research in cardiology - 21 Mar 2018

Ma Zhen-Guo, Dai Jia, Yuan Yu-Pei, Bian Zhou-Yan, Xu Si-Chi, Jin Ya-Ge, Zhang Xin, Tang Qi-Zhu

Abstract excerpt

Previous studies have suggested the involvement of CD4 + T lymphocytes in cardiac remodelling. T-bet can direct Th1 lineage commitment. This study aimed to investigate the functional significance of T-bet in cardiac remodelling induced by pressure overload using T-bet global knockout rats. Increased T-bet levels were observed in rodent and human hypertrophied hearts. T-bet deficiency resulted in a less severe...

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Identifiers

PMID: 29564567
DOI: 10.1007/s00395-018-0678-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.