Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

doi:10.1172/jci.insight.96244

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Article

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

JCI insight - 22 Mar 2018

Orabona Ciriana, Mondanelli Giada, Pallotta Maria T, Carvalho Agostinho, Albini Elisa, Fallarino Francesca, Vacca Carmine, Volpi Claudia, Belladonna Maria L, Berioli Maria G, Ceccarini Giulia, Esposito Susanna Mr, Scattoni Raffaella, Verrotti Alberto, Ferretti Alessandra, De Giorgi Giovanni, Toni Sonia, Cappa Marco, Matteoli Maria C, Bianchi Roberta, Matino Davide, Iacono Alberta, Puccetti Matteo, Cunha Cristina, Bicciato Silvio, Antognelli Cinzia, Talesa Vincenzo N, Chatenoud Lucienne, Fuchs Dietmar, Pilotte Luc, Van den Eynde Benoît, Lemos Manuel C, Romani Luigina, Puccetti Paolo, Grohmann Ursula

Abstract excerpt

A defect in indoleamine 2,3-dioxygenase 1 (IDO1), which is responsible for immunoregulatory tryptophan catabolism, impairs development of immune tolerance to autoantigens in NOD mice, a model for human autoimmune type 1 diabetes (T1D). Whether IDO1 function is also defective in T1D is still unknown. We investigated IDO1 function in sera and peripheral blood mononuclear cells (PBMCs) from children with T1D and...

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Identifiers

PMID: 29563329
DOI: 10.1172/jci.insight.96244
PMCID: PMC5926942

Genes

IDO1

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