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Article

Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2011

Dang MyLinh, Rockell Jennifer, Wagner Rebecca, Wenzlau Janet M, Yu Liping, Hutton John C, Gottlieb Peter A, Davidson Howard W

Abstract excerpt

Recently we demonstrated that zinc transporter 8 (ZnT8) is a major target of autoantibodies in human type 1 diabetes (T1D). Because the molecules recognized by T1D autoantibodies are typically also targets of autoreactive T cells, we reasoned that this would likely be the case for ZnT8. To test this hypothesis, IFN-γ-producing T cells specific for ZnT8 in the peripheral blood of 35 patients with T1D (<6 mo after...

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Source

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Identifiers

PMID: 21471440
DOI: 10.4049/jimmunol.1003815
PMCID: PMC3088514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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