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Article

The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2022

Merlo Lauren M F, Peng Weidan, DuHadaway James B, Montgomery James D, Prendergast George C, Muller Alexander J, Mandik-Nayak Laura

Abstract excerpt

IDO2 is one of two closely related tryptophan catabolizing enzymes induced under inflammatory conditions. In contrast to the immunoregulatory role defined for IDO1 in cancer models, IDO2 has a proinflammatory function in models of autoimmunity and contact hypersensitivity. In humans, two common single-nucleotide polymorphisms have been identified that severely impair IDO2 enzymatic function, such that <25% of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34965962
DOI: 10.4049/jimmunol.2100705
PMCID: PMC8770583

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