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Article

SAC-1 ensures epithelial endocytic recycling by restricting ARF-6 activity.

The Journal of cell biology - 4 Jun 2018

Chen Dan, Yang Chao, Liu Sha, Hang Weijian, Wang Xianghong, Chen Juan, Shi Anbing

Abstract excerpt

Arf6/ARF-6 is a crucial regulator of the endosomal phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) pool in endocytic recycling. To further characterize ARF-6 regulation, we performed an ARF-6 interactor screen in Caenorhabditis elegans and identified SAC-1, the homologue of the phosphoinositide phosphatase Sac1p in yeast, as a novel ARF-6 partner. In the absence of ARF-6, basolateral endosomes show a loss of...

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Identifiers

PMID: 29563216
DOI: 10.1083/jcb.201711065
PMCID: PMC5987724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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