Article

Shared and specific functions of Arfs 1–5 at the Golgi revealed by systematic knockouts

2021-04-19

Abstract excerpt

The ADP-ribosylation factors (Arfs) are small GTPases regulating membrane traffic in the secretory pathway. They are closely related and appear to have overlapping functions, regulators, and effectors. The functional specificity of individual Arfs and the extent of redundancy in vivo are still largely unknown. We addressed these questions by CRISPR/Cas9-mediated genomic deletion of the human class I (Arfs 1 and 3...

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Literature Corpus work: 1434c354-a80f-546c-a5c8-9e3e184024ee
DOI: 10.1101/2021.04.19.440443

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