Article
Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase.
Traffic (Copenhagen, Denmark) - 1 Feb 2005
Tahirovic Sabina, Schorr Markus, Mayinger Peter
Abstract excerpt
Phosphatidylinositol 4-phosphate (PtdIns(4)P) regulates diverse cellular processes, such as actin cytoskeletal organization, Golgi trafficking and vacuolar biogenesis. Synthesis and turnover of PtdIns(4)P is mediated by a set of specific lipid kinases and phosphatases. Here we show that the polyphosphoinositide phosphatase Sac1p has a central role in compartment-specific regulation of PtdIns(4)P. We have found...
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