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The AGEF-1/ARF-1 GTPase/AP-1 trafficking pathway differentially regulates LIN-12/Notch signaling in a tissue specific manner in <i>C. elegans</i>

2026-04-21

Abstract excerpt

LIN-12/Notch signaling regulates C. elegans vulval development via cell fate specifications in the gonad and epidermis. In the somatic gonad LIN-12/Notch activity specifies the anchor cell (AC) versus ventral uterine cell (VU) fates, with VU receiving more signal. The AC secretes epidermal growth factor (EGF) which induces the underlying vulval precursor cells (VPCs) to adopt vulval fates. In the VPCs the seconda...

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Literature Corpus work
ac1a1018-056d-5e6c-88e6-b5579c1a27f2
DOI
10.64898/2026.04.17.719071
Open publication

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