Article
Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing.
The Journal of experimental medicine - 7 Sept 2020
Li Xin, Gong Liying, Meli Alexandre P, Karo-Atar Danielle, Sun Weili, Zou Yongrui, King Irah L, Gu Hua
Abstract excerpt
Antigen uptake and presentation by naive and germinal center (GC) B cells are different, with the former expressing even low-affinity BCRs efficiently capture and present sufficient antigen to T cells, whereas the latter do so more efficiently after acquiring high-affinity BCRs. We show here that antigen uptake and processing by naive but not GC B cells depend on Cbl and Cbl-b (Cbls), which consequently control...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Antibody Formation
- Antigen Presentation
- Antigens, CD
- B-Lymphocytes
- Cell Communication
- Endocytosis
- Germinal Center
- Immunity, Humoral
- Intestines
- Lymphocyte Activation
- Lysosomes