Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing.

The Journal of experimental medicine - 7 Sept 2020

Li Xin, Gong Liying, Meli Alexandre P, Karo-Atar Danielle, Sun Weili, Zou Yongrui, King Irah L, Gu Hua

Abstract excerpt

Antigen uptake and presentation by naive and germinal center (GC) B cells are different, with the former expressing even low-affinity BCRs efficiently capture and present sufficient antigen to T cells, whereas the latter do so more efficiently after acquiring high-affinity BCRs. We show here that antigen uptake and processing by naive but not GC B cells depend on Cbl and Cbl-b (Cbls), which consequently control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Formation
Share to Antigen Presentation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Germinal Center

Share to Immunity, Humoral

Share to Proto-Oncogene Proteins c-cbl

Share to Receptors, Antigen, B-Cell

Share to T-Lymphocytes, Helper-Inducer

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 32584413
DOI: 10.1084/jem.20191537
PMCID: PMC7478728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing.PMID 32584413Read ↗

Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.Semantic proximity Read ↗

The Ins and Outs of Antigen Uptake in B cellsSemantic proximity Read ↗

Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.Semantic proximity Read ↗

B-Cell Receptor Signaling and Beyond: The Role of Igα (CD79a)/Igβ (CD79b) in Normal and Malignant B Cells.Semantic proximity Read ↗

T follicular helper cells in germinal center B cell selection and lymphomagenesis.Semantic proximity Read ↗

TFH cells progressively differentiate to regulate the germinal center response.Semantic proximity Read ↗

Modulation of Immune Cell Functions by the E3 Ligase Cbl-bSemantic proximity Read ↗

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses.Semantic proximity Read ↗

Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone.Semantic proximity Read ↗

The germinal center in the pathogenesis of B cell lymphomasSemantic proximity Read ↗

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.Semantic proximity Read ↗

The germinal center: a crucible for lymphocyte selection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.