Article
Pan-neuronal expression of human mutant SOD1 in Drosophila impairs survival and motor performance, induces early neuroinflammation and chromosome aberrations.
Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2024
Liguori Francesco, Alberti Francesca, Amadio Susanna, Angelini Daniela Francesca, Pilesi Eleonora, Vitale Giuseppe, Tesoriere Giulia, Borsellino Giovanna, Vernì Fiammetta, Volonté Cinzia
Abstract excerpt
Several mutations in the SOD1 gene encoding for the antioxidant enzyme Superoxide Dismutase 1, are associated with amyotrophic lateral sclerosis, a rare and devastating disease characterized by motor neuron degeneration and patients' death within 2-5 years from diagnosis. Motor neuron loss and related symptomatology manifest mostly in adult life and, to date, there is still a gap of knowledge on the precise...
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