Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DJ-1 knockout augments disease severity and shortens survival in a mouse model of ALS.

PloS one - 1 Jan 2015

Lev Nirit, Barhum Yael, Lotan Itay, Steiner Israel, Offen Daniel

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, neurodegenerative disorder, characterized by the degeneration of motor neurons. Oxidative stress plays a central role in the disease progression, in concert with an enhanced glutamate excitotoxicity and neuroinflammation. DJ-1 mutations, leading to the loss of functional protein, cause familial Parkinson's disease and motor neuron disease in several...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gliosis
Share to Glutamic Acid
Share to Motor Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF-E2-Related Factor 2

Share to Oncogene Proteins

Share to Protein Deglycase DJ-1

Share to Spinal Cord

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 25822630
DOI: 10.1371/journal.pone.0117190
PMCID: PMC4379040

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DJ-1 knockout augments disease severity and shortens survival in a mouse model of ALS.PMID 25822630Read ↗

Oxidative stress in ALS: key role in motor neuron injury and therapeutic target.Semantic proximity Read ↗

Pathogenesis of DJ-1/PARK7-Mediated Parkinson’s DiseaseSemantic proximity Read ↗

Molecular and Physiological Determinants of Amyotrophic Lateral Sclerosis: What the DJ-1 Protein Teaches Us.Semantic proximity Read ↗

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.Semantic proximity Read ↗

Pan-neuronal expression of human mutant SOD1 in Drosophila impairs survival and motor performance, induces early neuroinflammation and chromosome aberrations.Semantic proximity Read ↗

Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.Semantic proximity Read ↗

SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS.Semantic proximity Read ↗

Pathological Sequelae Associated with Skeletal Muscle Atrophy and Histopathology in G93A*SOD1 MiceSemantic proximity Read ↗

Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo.Semantic proximity Read ↗

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in miceSemantic proximity Read ↗

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damageSemantic proximity Read ↗

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.