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Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster.

Neurotoxicology - 1 Mar 2024

Adedara Adeola Oluwatosin, Bressan Getúlio Nicola, Dos Santos Matheus Mulling, Fachinetto Roselei, Abolaji Amos Olalekan, Barbosa Nilda Vargas

Abstract excerpt

The study investigated the protective effects of Hesperetin (HSP) and Hesperidin (HSD) on 1 methyl, 4 phenyl, 1,2,3,6 tetrahydropyridine hydrochloride (MPTP)-induced Parkinsonism in Drosophila melanogaster (D. melanogaster). After a lifespan study to select exposure time and concentrations, flies were co-exposed to MPTP (0.4 mg/g diet), Hesperetin (0.2 and 0.4 mg/g diet), and Hesperidin (0.1 and 0.4 mg/g) for 7...

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PMID: 38423185
DOI: 10.1016/j.neuro.2024.02.006

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