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Fisetin prevents deterioration of cellular functions in amyotrophic lateral sclerosis variants G262R and P438L of SQSTM1 in SH-SY5Y cells.

Toxicology and applied pharmacology - 1 Oct 2026

Singh Nidhi, Gomes James

Abstract excerpt

Oxidative stress is widely accepted as one of the important factors contributing to neurodegeneration, leading to fatal neurodegenerative diseases (NDD) such as Amyotrophic Lateral Sclerosis. Since flavonoids possess antioxidant properties, we investigated whether Fisetin (FS) and Quercetin (QR) protected cells from oxidative stress arising from pathogenic mutations G262R (G > A) and P438L (C > T) of SQSTM1 found...

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Identifiers

PMID: 42431556
DOI: 10.1016/j.taap.2026.117943

Genes

SQSTM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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