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MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

3 Aug 2009

Abstract excerpt

Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially contributing to pathogenesis of myeloid malignancies. Several of these diseases, such as myelodysplastic syndromes (MDSs), are responsive to DNA methyltransferase inhibitors. To determine the extent of promoter hypermethylation in such tumors, we compared the distribution of DNA methylation of 14 000 promoters in MDS and...

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PMID: 19652201
DOI: 10.1182/blood-2009-01-200519

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