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Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation

6 Apr 2023

Abstract excerpt

Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase of polycomb repressive complex 2 (PRC2) that catalyzes H3K27 tri-methylation. Aberrant expression and loss-of-function mutations of EZH2 have been demonstrated to be tightly associated with the pathogenesis of various myeloid malignancies characterized by ineffective erythropoiesis, such as myelodysplastic syndrome (MDS). However, the function and...

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PMID: 37021526
DOI: 10.3324/haematol.2022.282016

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