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Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture

28 Jun 2021

Abstract excerpt

Abstract The hematopoietic stem cell (HSC) niche has been extensively studied in bone marrow, yet a more systematic investigation into the microenvironment regulation of hematopoiesis in fetal liver is necessary. Here we investigate the spatial organization and transcriptional profile of individual cells in both wild type (WT) and Tet2 − / − fetal livers, by multiplexed error robust fluorescence in situ...

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PMID: 34183665
DOI: 10.1038/s41421-021-00266-1

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