Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii.

The Journal of antimicrobial chemotherapy - 1 Jun 2018

Gerson Stefanie, Nowak Jennifer, Zander Esther, Ertel Julia, Wen Yurong, Krut Oleg, Seifert Harald, Higgins Paul G

Abstract excerpt

Objectives: To investigate the mechanisms of tigecycline resistance in isogenic Acinetobacter baumannii isolate pairs as well as 65 unique clinical A. baumannii isolates obtained during the MagicBullet clinical trial from Greece, Italy and Spain. Methods: A. baumannii isolates were subjected to WGS and the regulatory genes of resistance-nodulation-cell division (RND)-type efflux pumps were analysed. MICs were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acinetobacter baumannii
Share to Acinetobacter Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Clinical Trials as Topic

Share to Drug Resistance, Multiple, Bacterial

Share to Genes, Regulator

Share to Greece

Share to Whole Genome Sequencing

Source

Identifiers

PMID: 29554339
DOI: 10.1093/jac/dky083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii.PMID 29554339Read ↗

Characteristics and diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with drug-resistant clinical isolates of Acinetobacter baumannii.Semantic proximity Read ↗

Characteristics and Diversity of Mutations in Regulatory Genes of Resistance-nodulation-cell Division Efflux Pumps in Association With Drug-resistant Clinical Isolates of Acinetobacter BaumanniiSemantic proximity Read ↗

The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible Acinetobacter baumannii in China.Semantic proximity Read ↗

AdeABC-mediated efflux and tigecycline MICs for epidemic clones of Acinetobacter baumanniiSemantic proximity Read ↗

Expression of the resistance-nodulation-cell division pump AdeIJK in Acinetobacter baumannii is regulated by AdeN, a TetR-type regulator.Semantic proximity Read ↗

Genome analysis of tigecycline-resistant Acinetobacter baumannii reveals nosocomial lineage shifts and novel resistance mechanisms.Semantic proximity Read ↗

RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations.Semantic proximity Read ↗

A truncated AdeS kinase protein generated by ISAba1 insertion correlates with tigecycline resistance in Acinetobacter baumannii.Semantic proximity Read ↗

Coexistence of blaNDM-1, blaOXA-51, blaOXA-23, and armA in conjunction with novel mutations detected in RND efflux pump regulators in tigecycline resistant clinical isolates of Acinetobacter baumannii.Semantic proximity Read ↗

Role of efflux pumps in reduced susceptibility to tigecycline in Acinetobacter baumanniiSemantic proximity Read ↗

Resistance associated genomic variations for moderate level tigecycline resistance evolution in Acinetobacter baumannii.Semantic proximity Read ↗

Molecular Characterization of Tigecycline Non-Susceptibility among Extensively Drug-Resistant Acinetobacter baumannii Isolates of Clinical Origin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.