Article
Coexistence of blaNDM-1, blaOXA-51, blaOXA-23, and armA in conjunction with novel mutations detected in RND efflux pump regulators in tigecycline resistant clinical isolates of Acinetobacter baumannii.
Pathogens and disease - 21 Jul 2022
Sawant Ajit Ramesh, Pagal Sudhakar, Amar Ashutosh Kumar, Panda Lipsa, Devi C Sheela, Shashikala P, Kanungo Reba, Prashanth K
Abstract excerpt
This study has investigated a total of 51 Acinetobacter baumannii isolates for the prevalence of resistant determinants in tigecycline susceptible and non-susceptible clinical isolates of A. baumannii. Antimicrobial susceptibility testing revealed 74% of isolates were tigecycline resistant. Mutations in RND-efflux pump regulatory genes and the expression of efflux pump genes were measured in tigecycline resistant...
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