Article
The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible Acinetobacter baumannii in China.
International journal of medical microbiology : IJMM - 1 Dec 2020
Xu Qingye, Hua Xiaoting, He Jintao, Zhang Di, Chen Qiong, Zhang Linghong, Loh Belinda, Leptihn Sebastian, Wen Yurong, Higgins Paul G, Yu Yunsong, Zhou Zhihui
Abstract excerpt
OBJECTIVE: Acinetobacter baumannii has emerged as a problematic hospital pathogen and tigecycline is among the few remaining antibiotics retaining activity against multidrug-resistant A. baumannii. This study was aimed to elucidate the tigecycline resistance mechanisms in 28 unique clinical A. baumannii strains from nine provinces in China. METHODS: Whole genome sequences were obtained via Illumina HiSeq...
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