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Article

RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations.

Antimicrobial agents and chemotherapy - 1 Jul 2013

Yoon Eun-Jeong, Courvalin Patrice, Grillot-Courvalin Catherine

Abstract excerpt

Increased expression of chromosomal genes for resistance-nodulation-cell division (RND)-type efflux systems plays a major role in the multidrug resistance (MDR) of Acinetobacter baumannii. However, the relative contributions of the three most prevalent pumps, AdeABC, AdeFGH, and AdeIJK, have not been evaluated in clinical settings. We have screened 14 MDR clinical isolates shown to be distinct on the basis of...

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Identifiers

PMID: 23587960
DOI: 10.1128/AAC.02556-12
PMCID: PMC3697384

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Source receipt: pubmed, retrieved 7 Sept 2026.

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RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations.PMID 23587960Read ↗

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