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Article

Expression of the resistance-nodulation-cell division pump AdeIJK in Acinetobacter baumannii is regulated by AdeN, a TetR-type regulator.

Antimicrobial agents and chemotherapy - 1 May 2012

Rosenfeld Nicolas, Bouchier Christiane, Courvalin Patrice, Périchon Bruno

Abstract excerpt

Resistance-nodulation-division efflux system AdeIJK contributes to intrinsic resistance to various drug classes in Acinetobacter baumannii. By whole-genome sequencing, we have identified in clinical isolate BM4587 the adeN gene, located 813 kbp upstream from adeIJK, which encodes a TetR transcriptional regulator. In one-step mutant BM4666 overexpressing adeIJK, the deletion of cytosine 582 (C(582)) in the 3'...

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Identifiers

PMID: 22371895
DOI: 10.1128/AAC.06422-11
PMCID: PMC3346617

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Source receipt: pubmed, retrieved 7 Sept 2026.

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