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Article

AdeABC-mediated efflux and tigecycline MICs for epidemic clones of Acinetobacter baumannii

16 Jun 2010

Abstract excerpt

OBJECTIVES: Tigecycline non-susceptibility in individual Acinetobacter baumannii isolates has been associated with up-regulation of the resistance-nodulation-division (RND)-type efflux system, AdeABC. We sought to relate variation in the expression of this system to differences in modal tigecycline MIC among prevalent A. baumannii clones. The role of AdeABC in the emergence of tigecycline resistance during...

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PMID: 20554571
DOI: 10.1093/jac/dkq218

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