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Article

A truncated AdeS kinase protein generated by ISAba1 insertion correlates with tigecycline resistance in Acinetobacter baumannii.

PloS one - 1 Jan 2012

Sun Jun-Ren, Perng Cherng-Lih, Chan Ming-Chin, Morita Yuji, Lin Jung-Chung, Su Chih-Mao, Wang Wei-Yao, Chang Tein-Yao, Chiueh Tzong-Shi

Abstract excerpt

Over-expression of AdeABC efflux pump stimulated continuously by the mutated AdeRS two component system has been found to result in antimicrobial resistance, even tigecycline (TGC) resistance, in multidrug-resistant Acinetobacter baumannii (MRAB). Although the insertion sequence, ISAba1, contributes to one of the AdeRS mutations, the detail mechanism remains unclear. In the present study we collected 130...

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Identifiers

PMID: 23166700
DOI: 10.1371/journal.pone.0049534
PMCID: PMC3498117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A truncated AdeS kinase protein generated by ISAba1 insertion correlates with tigecycline resistance in Acinetobacter baumannii.PMID 23166700Read ↗

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