Genome analysis of tigecycline-resistant Acinetobacter baumannii reveals nosocomial lineage shifts and novel resistance mechanisms.

doi:10.1093/jac/dkae314

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Article

Genome analysis of tigecycline-resistant Acinetobacter baumannii reveals nosocomial lineage shifts and novel resistance mechanisms.

The Journal of antimicrobial chemotherapy - 4 Nov 2024

Qian Changrui, Hu Panjie, Guo Wenhui, Han Yijia, Yu Pingting, Zhang Yi, Ma Zhexiao, Chen Lijiang, Zhou Tieli, Cao Jianming

Abstract excerpt

OBJECTIVES: To investigate the characteristics and clonal dynamics of tigecycline-resistant Acinetobacter baumannii (TRAB) isolates from a Chinese hospital from 2016 to 2021. METHODS: A total of 64 TRAB isolates were screened and WGS was performed. Phylogenetic analysis and non-polymorphic mutation analysis were used to analyse their clonal dynamics and tigecycline resistance-related mutations. RT-PCR was used to...

Topics

Acinetobacter baumannii
Tigecycline
Humans
Anti-Bacterial Agents
Acinetobacter Infections
Microbial Sensitivity Tests
Whole Genome Sequencing
Genome, Bacterial
Phylogeny
Cross Infection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

China

Drug Resistance, Multiple, Bacterial

Bacterial Proteins

Membrane Transport Proteins

Mutation

Drug Resistance, Bacterial

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Open in PubMed

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PMID: 39287979
DOI: 10.1093/jac/dkae314

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