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Article

Genome analysis of tigecycline-resistant Acinetobacter baumannii reveals nosocomial lineage shifts and novel resistance mechanisms.

The Journal of antimicrobial chemotherapy - 4 Nov 2024

Qian Changrui, Hu Panjie, Guo Wenhui, Han Yijia, Yu Pingting, Zhang Yi, Ma Zhexiao, Chen Lijiang, Zhou Tieli, Cao Jianming

Abstract excerpt

OBJECTIVES: To investigate the characteristics and clonal dynamics of tigecycline-resistant Acinetobacter baumannii (TRAB) isolates from a Chinese hospital from 2016 to 2021. METHODS: A total of 64 TRAB isolates were screened and WGS was performed. Phylogenetic analysis and non-polymorphic mutation analysis were used to analyse their clonal dynamics and tigecycline resistance-related mutations. RT-PCR was used to...

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PMID: 39287979
DOI: 10.1093/jac/dkae314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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