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Article

Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation

3 Apr 2017

Abstract excerpt

channel KCNQ1 has been proposed as a tumor suppressor in colorectal cancer (CRC). We investigated the molecular mechanisms regulating KCNQ1:β-catenin bidirectional interactions and their effects on CRC differentiation, proliferation, and invasion. Molecular and pharmacologic approaches were used to determine the influence of KCNQ1 expression on the Wnt/β-catenin signaling and epithelial-to-mesenchymal transition...

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Share to Genetic factors in colorectal cancer
Share to Ion channel regulation and function
Share to Wnt/β-catenin signaling in development and cancer

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PMID: 28373572
DOI: 10.1073/pnas.1702913114

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